Pristupačnost
Zvanje: redoviti profesor u trajnom izboru
prijediplomski
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1. Marijana Hranjec, Kristina Starčević, Branimir Zamola, Stjepan Mutak, Marko Đerek, Grace Karminski-Zamola, New Amidino-benzimidazolyl Derivatives of Tylosin and Desmycosin. Journal of Antibiotics 55 (2002) 308-314.
2. Dejan Agić, Marijana Hranjec, Nina Jajčanin, Kristina Starčević, Grace Karminski-Zamola, Marija Abramić, Novel amidino-substituted benzimidazoles: Synthesis of compounds and inhibition of dipeptidyl peptidase III. Bioorg. Chem. 35 (2007) 153-169.
3. Marijana Hranjec, Grace Karminski-Zamola, Synthesis of Novel Benzimidazolyl-substituted Acrylonitrilesand Amidino-substituted Benzimidazo[1,2-a]Quinolines. Molecules 12 (2007) 1817-1828.
4. Marijana Hranjec, Gordana Pavlović, Grace Karminski-Zamola, Spectroscopic characterization, crystal structure determination and interaction with DNA of novel cyano substituted benzimidazole derivative. Struct. Chem. 18 (2007) 943-949.
5. Marijana Hranjec, Marijeta Kralj, Ivo Piantanida, Mirela Sedić, Lidija Šuman, Krešimir Pavelić, Grace Karminski-Zamola, Novel cyano- and amidino-substituted derivatives of styryl-2-benzimidazoles and benzimidazo[1, 2-a]quinolines. Synthesis, photochemical synthesis, DNA binding, and antitumor evaluation, part 3. J. Med. Chem. 50 (2007) 5696-5711.
6. Kristina Starčević, Marijana Hranjec, Dejana Carić, Grace Karminski-Zamola, Synthesis and spectroscopic properties of new furyl-phenyl-acrylates and naphthofurans and their interaction with ct-DNA. Monatshefte für Chemie-Chemical Monthly 139 (2008) 975-983.
7. Marijana Hranjec, Gordana Pavlović, Marinela Marinović, Grace Karminski-Zamola, Synthesis, Spectroscopic properties and crystal structure determination of 2-(2-pyridin-4-yl-vinyl)-1H-benzimidazole derivatives. Struct. Chem. 19 (2008) 353-359.
8. Marijana Hranjec, Kristina Starčević, Ivo Piantanida, Marijeta Kralj, Marko Marjanović, Merima Hasani, Gunnar Westman, Grace Karminski-Zamola, Synthesis, antitumor evaluation and DNA binding studies of novel amidino- benzimidazolyl substituted derivatives of furyl-phenyl and thienyl-phenyl-acrylates, naphthofurans and naphthothiophenes. Eur. J. Med. Chem. 43 (2008) 2877-2890.
9. Mirela Sedic, Miroslav Poznic, Peter Gehrig, Mike Scott, Ralph Schlapbach, Marijana Hranjec, Grace Karminski Zamola, Kresimir Pavelić, Sandra Kraljević Pavelić, Differential anti-proliferative mechanisms of novel derivative of N-amidino-substituted benzimidazo[1,2-a]quinoline in colon cancer cells depending upon their functional p53 status. Mol. Canc. Ther. 7 (2008) 2121-2132.
10. Marijana Hranjec, Ivo Piantanida, Marijeta Kralj, Lidija Šuman, Krešimir Pavelić, Grace Karminski-Zamola, Novel amidino-substituted thienyl- and furyl-vinyl-benzimidazole derivatives and their photochemical conversion into corresponding diaza-cyclopenta[c]fluorenes. Synthesis, interactions with DNA and RNA and antitumor evaluation. Part 4. J. Med. Chem. 51 (2008) 4899-4910.
11. Sandra Kraljević Pavelić, Siniša Bratulić, Karlo Hock, Davor Jurišić, Marijana Hranjec, Grace Karminski-Zamola, Biserka Žinić, Maro Bujak, Krešimir Pavelić, Screening of potential prodrugs on cells derived from Dupuytren’ s Disease patients. Biomedicine & pharmacotherapy 63 (2009) 577-585.
12. Marijana Hranjec, Gordana Pavlović, Grace Karminski-Zamola, Crystal structure and synthesis of benzimidazole substituted acrylonitriles and benzimidazo[1,2-a]quinolines. Struct. Chem. 20 (2009) 91-99.
13. Katja Ester, Marijana Hranjec, Ivo Piantanida, Irena Ćaleta, Jarak Ivana, Krešimir Pavelić, Marijeta Kralj, Grace Karminski-Zamola, Novel Derivatives of Pyridyl-Benzo[b]thiophene-2-carboxamides and Benzo[b]thieno[2, 3- c]naphthyridin-2-ones: Minor Structural Variations Provoke Major Differences of Antitumor Action Mechanisms. J. Med. Chem. 52 (2009) 2482-2492.
14. Marijana Hranjec, Gordana Pavlović, Marko Marjanović, Grace Karminski-Zamola, Benzimidazole derivatives related to 2,3-acrylonitriles, benzimidazo[1,2-a]quinolines and fluorenes: Synthesis, Antitumor Evaluation in vitro and Crystal Structure Determination. Eur. J. Med. Chem. 45 (2010) 2405-2417.
15. Nataša Perin, Marijana Hranjec, Gordana Pavlović Grace Karminski-Zamola, Novel aminated benzimidazo[1,2-a]quinolines as potential fluorescent probes for DNA detection: microwave-assisted synthesis, spectroscopic characterization and crystal structure determination. Dyes and Pigments 91 (2011) 79-88.
16. Marijana Hranjec, Kristina Starčević, Sandra Kraljević Pavelić, Pero Lučin, Krešimir Pavelić and Grace Karminski-Zamola, Synthesis, spectroscopic characterization and antiproliferative evaluation in vitro of novel Schiff bases related to benzimidazoles. Eur. J. Med. Chem. 46 (2011) 2274-2279.
17. Marijana Hranjec, Borka Lučić, Ivana Ratkaj, Sandra Kraljević Pavelić, Ivo Piantanida, Krešimir Pavelić and Grace Karminski-Zamola, Novel Imidazo[4, 5-b]Pyridine and Triaza-Benzo[c]Fluorene Derivatives: Synthesis, Antiproliferative Activity and DNA Binding Studies. Eur. J. Med. Chem. 46 (2011) 2748-2758.
18. Nataša Perin, Lidija Uzelac, Ivo Piantanida, Grace Karminski-Zamola, Marijeta Kralj, Marijana Hranjec, Novel biologically active nitro and amino substituted benzimidazo[1, 2-a]quinolines. Bioorg. Med. Chem. 19 (2011) 6329-6339.
19. Marijana Hranjec, Gordana Pavlović, Grace Karminski-Zamola, Synthesis, crystal structure determination and antiproliferative activity of novel 2-amino-4-aryl-4, 10-dihydro[1,3,5]triazino[1,2-a]benzimidazoles. J. Mol. Struct. 1007 (2011) 242-251.
20. Marijana Hranjec, Ema Horak Martina Tireli, Gordana Pavlović, Grace Karminski-Zamola, Synthesis, crystal structure and spectroscopic study of novel benzimidazoles and benzimidazo[1,2-a]quinolines as potential chemosensors for different cations. Dyes and pigments. 95 (2012) 644-656.
21. Marijana Hranjec, Irena Sović, Ivana Ratkaj, Gordana Pavlović, Nataša Ilić, Linda Valjalo, Krešimir Pavelić, Sandra Kraljević Pavelić, Grace Karminski-Zamola, Antiproliferative potency of novel benzofuran-2-carboxamides on tumour cell lines: Cell death mechanisms and determination of crystal structure. Eur. J. Med. Chem. 59 (2013) 111-119.
22. Perin, Nataša; Nhili, Raja; Ester, Katja; Laine, William; Karminski-Zamola, Grace; Kralj, Marijeta; David-Cordonnier, Marie-Helene; Hranjec, Marijana*. Synthesis, antiproliferative activity and DNA binding properties of novel 5-aminobenzimidazo[1,2-a]quinoline-6-carbonitriles. Eur. J. Med. Chem. 80 (2014) 218-227.
23. de Souza, I.O.; Schrekker, Clarissa M.L.; Lopes, William; Orru, Romano V.A.; Hranjec, Marijana; Perin, Nataša; Machado, Michel; Oliveira, Luís F.; Donato, Ricardo K.; Stefani, Valter et al. Bifunctional Fluorescent Benzimidazo[1,2-a]quinolines for Candida spp. Biofilm Detection and Biocidal Activity. J. Photochem. Photobiol. B, Biology 163 (2016) 319-326.
24. Perin, Nataša; Bobanović, Kristina; Zlatar, Ivo; Jelić, Dubravko; Kelava, Vanja; Koštrun, Sanja; Gabelica Marković, Vesna; Brajša, Karmen; Hranjec, Marijana*. Antiproliferative activity of amino substituted benzo[b]thieno[2,3-b]pyrido[1,2-a]benzimidazoles explored by 2D and 3D cell culture system. . Eur. J. Med. Chem. 125 (2017) 722-735.
25. Perin, Nataša; Hok, Lucija; Beč, Anja; Persoons, Leentje; Vanstreels, Els; Daelemans, Dirk; Vianello, Robert; Hranjec, Marijana*. N-substituted benzimidazole acrylonitriles as in vitro tubulin polymerization inhibitors: Synthesis, biological activity and computational analysis. . Eur. J. Med. Chem. 211 (2021) 113003, 14.
26. Lončar, Borka; Perin, Nataša; Mioč, Marija; Boček, Ida; Grgić, Lea; Kralj, Marijeta; Tomić, Sanja; Radić Stojković, Marijana; Hranjec, Marijana*. Novel amino substituted tetracyclic imidazo[4,5-b]pyridine derivatives: Design, synthesis, antiproliferative activity and DNA/RNA binding study. Eur. J. Med. Chem. 217 (2021) 113342-113342.
27. Boček, Ida; Hok, Lucija; Persoons, Leentje; Daelemans, Dirk; Vianello, Robert; Hranjec, Marijana*. Imidazo[4,5-b]pyridine derived tubulin polymerization inhibitors: Design, synthesis, biological activity in vitro and computational analysis. Bioorg, Chem. 127 (2022) 106032, 13.
28. Beč, Anja; Mioč, Marija; Bertoša, Branimir; Kos, Marija; Debogović, Patricia; Kralj, Marijeta; Starčević, Kristina; Hranjec, Marijana*. Design, synthesis, biological evaluation and QSAR analysis of novel N-substituted benzimidazole derived carboxamides. J. Enz. Inhib. Med. Chem. 37 (2022) 1327-1339.
29. Racané Livio; Zlatić Katarina; Cindrić Maja; Mehić Emina; Karminski-Zamola, Grace; Taylor C,. Martin; Kelly M., John; Malić Raić, Silvana; Stojković Radić, Marijana; Kralj, Marijeta; Hranjec, Marijana*.. Synthesis and Biological Activity of 2-Benzo[b]thienyl and 2-Bithienyl Amidino-Substituted Benzothiazole and Benzimidazole Derivatives. ChemMedChem 18 (2023) e202300261.
30. Boček Pavlinac, Ida; Zlatić, Katarina; Persoons, Leentje; Daelemans, Dirk; Banjanac, Mihailo; Radovanović, Vedrana; Butković, Kristina; Kralj, Marijeta; Hranjec, Marijana*. Biological Activity of Amidino-Substituted Imidazo[4,5-b]pyridines. Molecules 28 (2023) 1-16.
Područje rada: Organska sintetska kemija, sinteza heterocikličkih spojeva, sinteza i fotokemijska sinteza te spektroskopska karakterizacija heterocikličkih spojeva (posebno benzimidazola i amidina) koji se priređuju kao supstancije s potencijalnom biološkom aktivnošću, s ciljem njihovih selektivnih ili specifičnih interakcija s biomakromolekulama, uglavnom DNA i RNA. Spektroskopska ispitivanja interakcije novih biološki aktivnih molekula u otopini u s DNA/RNA. Spektroskopska karakterizacija spojeva korištenjem UV/Vis i fluorimetrijske spektroskopije u svrhu moguće primjene novopriređenih spojeva kao senzora za detekciju pH ili metalnih kationa u otopinama; ispitivanje antioksidativnog potencijala benzazola spektroskopskim i elektrokemijskim metodama.
Članstva: Hrvatsko kemijsko društvo i AMACIZ
2011.-2012. voditeljica projekta Sinteza, fotokemijska sinteza, vezivanje na DNA, antitumorska aktivnost i QSAR analiza novih kondenziranih kinolona i kinolina, COGITO Partnerstvo Hubert Curien - hrvatsko-francuski projekt
2011.-2014. voditeljica projekta Novi heterocikli kao antitumorski i antivirusni („pametni“) lijekovi (125-0982464-1356), nacionalni projekt financiran od MZOS
2014.-2018. suradnica na projektu Synthesis and cytostatic evaluations of novel nitrogen heterocycles library (5596), HRZZ
2015-2019. suradnica na projektu Design and Synthesis of Novel Nitrogen-Containing Heterocyclic Fluorophores and Fluorescent Nanomaterials for pH and Metal- Ion Sensing (3386), HRZZ
2018.-2023. voditeljica projekta Istraživanje antioksidativnog djelovanja benzazolskog skeleta u dizajnu novih antitumorskih agensa (AntioxPot), HRZZ
2021-2025 - suradnik na projektu Dizajn, sinteza i računalna analiza novih optičkih kemijskih pH osjetilnih derivata benzazola (8090) voditelja dr. sc. Roberta Vianella (IRB), HRZZ
01.09.2001. do 01.09. 2008. - znanstvena novakinja
01.09.2008. do 27.12.2012. - docentica
27.12.2012. do 27.2.2018. - izvanredna profesorica
27.2.2018. do 17.4.2023. - redovita profesorica
od 18.4.2023. do danas - redovita profesorica u trajnom izboru
