Polymeric Biomaterials
PURPOSE:
Biomaterials are a part of materials science that has been developing very intensively in recent years. It is characterized by a distinct interdisciplinarity that implies the necessary cooperation of experts from a large number of scientific fields. The aim of the course is to get acquainted with the characteristic concepts: biocompatibility, toxicity, biodegradation; commonly used materials and their most important properties, surface and other characteristic properties and methods of determination, physicochemical methods of surface properties modification, examples of synthesis of biodegradable polymers, definition and classification of hydrogels, methods of testing biomaterials, ethical issues arising in working with biopolymers.
THE CONTENTS OF THE COURSE:
1. Introduction.
2. and 3. Definition of biocompatibility, toxicity, biodegradation. In vitro and in vivo biological evaluation of biomaterials.
4. Classification of biomaterials: polymers, silicones, fibers and textiles, hydrogels, natural materials. Classification of polymeric biomaterials: PU, PEG, polydioxanone (PDS), polyhydroxybutyrate (PHB), polyanhydrides, polyorthoesters (POE), polyphosphazenes, politrimetilkarbonat (PTMC), PCL, PLA, PGA, PLGA.
5. The structure, surface and mechanical properties of (bio) polymers. Methods for characterization of properties.
6. Polymer synthesis.
7. Physico-chemical methods of modification of surface properties.
8. Hydrogels: structure, classification.
9. Methods of production of hydrogels.
10. Swelling of hydrogels.
11. Bioresorbable and biodegradable materials.
12. Biodegradation: hydrolytic, oxidative.
13. Application of biomaterials in medicine: an intraocular lens (IOL), compresses, surgical sutures, drug delivery systems, bioelektrode, prostheses, biosensors.
14. Authorship. Legislation. Patents.
DEVELOPMENT OF GENERAL AND SPECIFIC COMPETENCIES OF STUDENTS:
Introduction to the properties, origin and applications of biomaterials. The importance of these materials is growing daily and a multidisciplinary scientific research approach is needed in their study given the diversity of applications.
STUDENTS 'TEACHING OBLIGATIONS AND THEIR PERFORMANCE:
Students are required to attend lectures.
Students are required to write a seminar paper.
Students are required to access knowledge tests.
TEACHING METHODS:
Lectures.
Presentation and discussion of seminar papers.
Consultations by arrangement with students.
METHOD OF EXAMINATION OF KNOWLEDGE AND EXAMINATION:
Written or oral exam.
METHOD OF MONITORING THE QUALITY AND PERFORMANCE OF COURSES:
Student survey.
METHODOLOGICAL PREREQUISITES:
General chemistry. Organic chemistry.
COURSE LEARNING OUTCOMES:
1. distinguish the characteristics of polymeric biomaterials in relation to other types of materials in terms of physical-mechanical, chemical and biological properties.
2. analyze certain types of polymeric biomaterials from the point of view of their application
3. analyze the reaction mechanisms and distinguish the processes of synthesis and preparation of polymeric biomaterials
4. analyze the application of biomaterials in medicine
5. distinguish the processes of bioresorption and biodegradability of materials
6. explain specifics in the development of materials used in medicine and pharmacy, in compliance with statutory protocols and ethics of research
LEARNING OUTCOMES AT PROGRAM LEVEL:
1. recognise major elements of materials science and engineering: structure, properties, processing and performance of materials
2. describe different types of materials (in particular mineral binders, ceramics, polymers, metals and alloys), their application and technologies of their processing
3. relate gained knowledge of materials, their application and processing
4. gather information from various sources
5. develop work ethics, personal responsibility and aspiration for further learning
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Polimerni biomaterijali, predavanja za studente FKIT-a (www.fkit.hr), Vidović, Elvira,
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Biomaterials Science: An introduction to Materials in Medicine, Odabrane cjeline, Buddy D. Ratner, Allan S. Hoffman, Frederick J. Schoen, Jack E. Lemons, Elsevier Academic Press, San Diego,, 2004.
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