1. komponenta

Lecture type	Total
Lectures	30
Laboratory exercises	30

* Load is given in academic hour (1 academic hour = 45 minutes)

Course objectives
To familiarize students with the principles of modern synthetic methods and their application in research and industry, planning synthesis and retrosynthetic analysis of organic molecules, and developing critical thinking in selecting the most appropriate synthetic pathways for organic synthesis in the laboratory.

Course content (syllabus)
WEEK 1. Introduction. Organic Synthesis Strategies: planning of synthesis and control. Retrosynthesis.
WEEK 2. Chemoselectivity, regioselectivity and stereoselectivity of choosen reaczions of organic synthesis.
WEEK 3. Formation of carbon-carbon single bonds
WEEK 4. Formation of carbon-carbon double bonds. Synthesis of double bonds with defines stereochemistry.
WEEK 5. Pericyclic reactions. Functionalization of alkenes.
WEEK 6. Oxidation and reduction reactions.
WEEK 7. PARTIAL EXAM
WEEK 8. Asymmetric synthesis with natural products as initial reactants. Asymmetric catalysis: creating C-C, C-H, C-O and C-N bonds. Enzymes: biological methods in asymmetric synthesis and bioorganometallic reactions.
WEEK 9. Microwave application in the synthesis of different classes of organic compounds. Theory of microwave synthesis and microwaves. Microwave reactors for organic synthesis.
WEEK 10. Microwave synthesis techniques as part of green chemistry. Microwave assisted scale-up of organic synthesis.
WEEK 11. Application of organometallic cross-linking reactions in modern organic synthesis.
WEEK 12. Domino reaction as one of the strategies of modern organic synthesis: cationic, anionic and enzymatic.
WEEK 13. Multicomponent reaction in liquid and solid state.
WEEK 14. Application of flow chemistry in the synthesis of heterocycles, biologically active compounds and natural products.
WEEK 15. PARTIAL EXAM
Work assignment

Format of instruction:
lectures
exercises
partial e-learning
laboratory

Monitoring student work
Class attendance
Experimental work
Preliminary exam
Practical work
Written exam
Independent and joint assignments

Learning outcomes at the level of the programme to which the course contributes
- Compile and apply advanced knowledge of natural and technical sciences, particularly chemical engineering and environmental engineering in solving scientific, professional and general social problems.
- Solve engineering problems using the scientific method combining expert knowledge from chemistry, environmental, and chemical engineering as well as material science and engineering.
- Plan and independently perform experiments in order to confirm a hypothesis to estimate economic and ecological efficiency of processes.
- Utilise advanced laboratory procedures and instruments for synthesis of new products, create sustainable processes, and solve problems of water, air and soil pollution.
- Identify and discuss advantages, disadvantages and limitations of certain methods for preparation, synthesis, analysis and processing of samples in accordance with sustainable development and life cycle of products and processes.
- Independently organise and plan timelines, apply a general methodology for project planning and management in a business environment
- Create a critical analysis, evaluation and interpretation of personal results, and compare them with existing data in scientific and expert literature
- Investigate and analyse implementation of innovative and incoming chemical technologies in multidisciplinary environment
- Demonstrate independence and reliability in independent work, as well as effectiveness, reliability and adaptability in team work
- Outline results of independent and teamwork in a written and oral form to non-experts and experts in a clear and coherent way.
- Develop work ethic, personal responsibility and tendency for further skill and knowledge acquisition, according to standards of engineering practice

Expected learning outcomes at the level of the course (3 to 10 learning outcomes)
1. to define the principles and problems related to simple and multistage organic synthesis
2. to analyze by using the retrosynthetic approach the structure of the target molecules and to explain, propose and present possible synthetic pathways
3. to select and propose the most suitable synthetic route for the synthesis of target molecules with respect to the available starting reagents
4. to explain and apply the principles of assisted microwave assisted, organometallic, domino and multicomponent reactions in a modern approach to organic synthesis
5. to synthesize selected target molecules using modern synthetic methods

1. to define the principles and problems related to simple and multistage organic synthesis
2. to analyze by using the retrosynthetic approach the structure of the target molecules and to explain, propose and present possible synthetic pathways
3. to select and propose the most suitable synthetic route for the synthesis of target molecules with respect to the available starting reagents
4. to explain and apply the principles of assisted microwave assisted, organometallic, domino and multicomponent reactions in a modern approach to organic synthesis
5. to synthesize selected target molecules using modern synthetic methods

1. ORGANIC SYNTHESIS: STRATEGY AND CONTROL, P. Wyatt, S. Warren, John Willey & Sons, New York, 2007.
2. ORGANOMETALLIC CHEMISTRY-RESEARCH PERSPECTIVES, Nova Science Publishing. Inc., New York, 2007., R. P. Irwin, Nova Science Publishing. Inc., New York, 2007.
3. ORGANIC CHEMISTRY, John Willey & Sons, New York, 2104., T. W. Graham Solomons,, John Willey & Sons, New York, 2104.
4. ORGANIC CHEMISTRY, Pearson, 8th Ed, 2013., l.G. Wade Jr, Pearson, 8th Ed, 2013.
5. DOMINO REACTIONS IN ORGANIC SYNTHESIS, L. F. Tietze, G. Brasche, K. M. Gericke, Willey VCH-Verlag, Weinheim, 2006.
6. PRACTICAL MICROWAVE SYNTHESIS FOR ORGANIC CHEMISTS, C. O. Kappe, D. Dallinger, S. S. Murphree, Wiley-WCH, Weinheim, 2009.

Izborni predmeti - Regular studij - Chemical and Environmental Technology