1. komponenta

Lecture type	Total
Lectures	20

* Load is given in academic hour (1 academic hour = 45 minutes)

Principle of medicinal chemistry: Drugs and receptors, Enzymes as targets for drug action, Strategies in drug development; Development of successful drugs: Inhibitors of angiotensin converting enzyme; Potassium and calcium channel blockers; Antagonists of histamine receptors (H2); Proton pump inhibitors and gastric acid secretion; Antidepressants; Ligands for benzodiazepine receptors; Blockers of the H1 receptors; Antibacterial DNA gyrase inhibitors; Inhibitors of human HIV reverse transcriptase, Anticancer drugs as antimetabolites, inhibitors of hormone action, DNA alkylating agents, Alkylating and nonalkylating compounds interacting with the DNA minor groove, DNA intercalators and topoisomerase I and II inhibitors, tubule and microtubule inhibitors, protein kinase inhibitors; PET as a tracer method in drug development, PET imaging in oncology, Radiohalogen for PET imaging, 18F and 11C Radiochemistry.

1. 1. To analyze critically medications according to the targets of their action.
2. 2. To interpret the mechanism of action of drugs with respect to their interaction with the receptor (enzyme) and/or DNA/RNA.
3. 3. To compare substrates and inhibitors of the enzyme in the strategy of drug development.
4. 4. To compare medicines developed by the rational approach based on their mechanisms of action with the older drugs and their newly discovered mechanisms of action.
5. 5. To connect the structural features of drugs with their biological properties.
6. 6. To present the mechanism of biological action based on the structure of the suggested compound to the competent audience.
7. 8. To propose the development of novel PET ligand with potential application on medicine.

1. An Introduction to Medicinal Chemistry, 6th edition, Graham Patrick, Oxford University Press, 2017.
2. Drugs: From Discovery to Approval, 3rd edition, Rick Ng, Wiley-Blackwell, 2015.
3. Medicinska kemija, M. Mintas, S. Raić-Malić, Medicinska naklada, 2009.
4. Positron Emission Tomography: Basic Sciences, D. L. Bailey, A. W. Townsend, P. E. Valk, M. N. Maisey, Springer Science & Business Media, 2005.
5. The Organic Chemistry of Drug Design and Drug Action 3rd edition, Richard B. Silverman, Mark W. Holladay, Elsevier Inc., 2014.
6. The Evolution of Drug Discovery: From Traditional Medicines to Modern Drugs, 1st edition,, Enrique Ravina, Hugo Kubinyi, Wiley-VCH, 2011.

D_Izborni - Regular studij - Chemical Engineering and Applied Chemistry