PURPOSE:
To familiarize with the group of materials characterized by a range of characteristics that is basis of their application for very specific purposes especially in medicine and pharmaceuticals. The most important properties of these materials, the most important representatives and ways of making them as preconditions for their successful use will be discussed.
THE CONTENTS OF THE COURSE:
1. Introduction.
2. and 3. Definition of biocompatibility, toxicity, biodegradation. In vitro and in vivo biological evaluation of biomaterials.
4. Classification of biomaterials: polymers, silicones, fibers and textiles, hydrogels, natural materials. Classification of polymeric biomaterials: PU, PEG, polydioxanone (PDS), polyhydroxybutyrate (PHB), polyanhydrides, polyorthoesters (POE), polyphosphazenes, politrimetilkarbonat (PTMC), PCL, PLA, PGA, PLGA.
5. The structure, surface and mechanical properties of (bio) polymers. Methods for characterization of properties.
6. Polymer synthesis.
7. Physico-chemical methods of modification of surface properties.
8. Hydrogels: structure, classification. Swelling of hydrogels.
9. Intelligent / smart polymers, pH sensitive and heat-sensitive hydrogels..
10. Bioresorbable and biodegradable materials. Biodegradation: hydrolytic, oxidative..
11. Application of biomaterials in medicine: intraocular lenses (IOL), compresses, surgical sutures, drug dosing systems, bioelectrodes, prostheses, biosensors.
12. Tissue engineering. Sterilization. Tests: in vivo, in vitro. Material application and standards. Authorship. Legislation. Patents.
13. and 14. Examples of methods of preparation and application of related materials from recent literature.
DEVELOPMENT OF GENERAL AND SPECIFIC COMPETENCIES OF STUDENTS:
To gather knowledge on the group of materials characterized by a range of characteristics that is basis of their application for very specific purposes especially in medicine and pharmaceuticals. The most important representatives of these materials and their properties, modern, advanced methods of their design and processing aiming at their successful use and application will be in focus.
STUDENTS 'TEACHING OBLIGATIONS AND THEIR PERFORMANCE:
Students are required to attend lectures.
Students are required to write a seminar paper.
Students are required to access knowledge tests.
TEACHING METHODS:
Lectures.
Presentation and discussion of seminar papers.
Consultations by arrangement with students.
METHOD OF EXAMINATION OF KNOWLEDGE AND EXAMINATION:
Written or oral exam.
METHOD OF MONITORING THE QUALITY AND PERFORMANCE OF COURSES:
Student survey.
METHODOLOGICAL PREREQUISITES:
General chemistry. Organic chemistry.
COURSE LEARNING OUTCOMES:
1. evaluate the characteristics of polymeric biomaterials in relation to other types of materials from the point of view of their structure and properties (physical-mechanical, chemical and biological)
2. analyze certain types of polymeric biomaterials from the point of view of application, with reference to the application in medicine and pharmacy
3. argue the impact of new technologies and production processes on the improvement and development of polymer (bio) materials
4. compare the application of standard and advanced analytical techniques for the analysis and development of polymeric (bio) materials
5. judge ethical issues in research focused on biomedical application
6. support the necessity of an interdisciplinary approach in the development of new complex scientific and technical ideas
LEARNING OUTCOMES AT PROGRAM LEVEL:
1. apply the more complex principles of chemistry built upon the foundations of the Bachelors degree
2. relate essential facts, concepts and chemical principles and theories relating to the advanced chemistry areas
3. integrate knowledge to handle complex ideas
46. objectively evaluate research results for their presentation
5. explain scientific or technical concepts, data, and conclusions with the knowledge and rationale underpinning them to both specialist and non-specialist audiences in written and oral form
6. develop interaction with scientists from other disciplines on inter or multidisciplinary problems
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Polimerni biomaterijali, predavanja za studente FKIT-a (www.fkit.hr), Elvira Vidović,
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Znanstveni članci iz područja, Odabrani,
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Principles of Tissue Engineering, Odabrani dijelovi, Robert Lanza, Robert Langer, Joseph Vacanti, Elsevier Academic Press, San Diego, 2007.
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