1. komponenta

Lecture type	Total
Lectures	30
Laboratory exercises	30

* Load is given in academic hour (1 academic hour = 45 minutes)

PURPOSE:
The main purpose of the course is to familiarize students with the design, synthesis and physiological mechanism of action of some antiviral and anticancer drugs.

LEARNING OUTCOMES AT PROGRAM LEVEL:
1. To apply more complex chemical principles that continue the basic knowledge of chemistry acquired in undergraduate study
2. To apply ideas within scientific research work
3. To connect basic facts, concepts, chemical principles and theories related to advanced areas of chemistry and chemical technologies
4. To integrate the knowledge needed to process complex ideas
5. To use advanced laboratory procedures and instrumentation within chemical synthesis and analysis

THE CONTENTS OF THE COURSE:
Antivirotics
1. Viral diseases, RNA- and DNA viruses, the structure of viruses. Strategy in developing anti-viral drugs.
2. Drugs against diseases caused by herpes viruses and HIV.
3. Nucleoside and non-nucleoside antiviral agents as inhibitors of replication of viral nucleic acid (interferons, zidovudine, acyclovir, idoxuridine, trifluorothymidine).
4. Acyclic and carbocyclic nucleoside analogs.
5. Inhibitors of ribosome translation (methisazone).
6. Protease inhibitors. Inhibitors of gene expression (oligonucleotides). Inhibitors of virus binding process
7. 1st test
Cytostatics
8. Cancer and chemotherapy of cancer. Antimetabolites.
9. Inhibitors of hormone activity. Selective modulators of estrogen receptors.
10. DNA-alkylating agents.
11. DNA-intercalators and topoisomerase inhibitors.
12. Inhibitors of tubules and microtubules formation.
13. Inhibitors of protein and receptor kinases. Proteasome inhibitors.
14. Presenting of seminar paper.
15. 2nd test.

GENERAL AND SPECIFIC COMPETENCE:
To introduce students with the basic principles of organic chemistry in the development of antivirotics and cytostatics, the main representatives of antiviral and anticancer agents and their structural characteristics, synthetic pathways for the preparation of some representatives of antivirotics and cytostatics and mechanisms of action of the compounds according to their targets.
KNOWLEDGE TESTING AND EVALUATION:
Two (2) partial tests during the semester. Students can be released from exam if they collect sufficient points (55) from 2 tests.
Written exam and oral exam.
MONITORING OF THE COURSE QUALITY AND SUCCESSFULNESS:
Student survey.
LITERATURE:
1) C. Avendano, J. C. Menendez, Medicinal Chemistry of Anticancer Drugs, Elsevier, Amsterdam, Belgija, 2008.
2) D. E. Thurston, Chemistry and Pharmacology of Anticancer Drugs, CRC Press, Taylor & Francis Group, New York, USA, 2007.
3) C. K. Chu, Antiviral Nucleosides: Chiral Synthesis and Chemotherapy, Elsevier, Amsterdam, Belgija, 2003.
4) E. De Clercq, Advances in Antiviral Drug Design, Elsevier Science, Ltd., Amsterdam, Belgija, 2004.
5) Mladen Mintas, Silvana Raić-Malić, Medicinska kemija, Medicinska naklada, Zagreb, 2009.
6) Nenad Raos, Silvana Raić-Malić, Mladen Mintas, Lijekovi u prostoru: farmakofori i receptori, Školska knjiga, Zagreb, 2005.

1. 1. To categorize viruses and compare their replication cycles
2. 2. To select representatives of antivirals in the treatment of infections caused by viruses and to explain their synthesis
3. 3. To analyze the biochemical mechanism of action for drugs according to the targets of their action
4. 4. To explain the etiology of cancer - cell dysregulations that cause uncontrolled growth of tumor cells
5. 5. To select cytostatics of appropriate therapeutic groups, to analyze the mechanistic principle of their inhibitory effects on key enzymes that inhibit the growth of tumor cells and cause their programmed death

1. C. Avendano, J. C. Menendez, Medicinal Chemistry of Anticancer Drugs, Elsevier, Amsterdam, Belgija, 2008.,
2. C. K. Chu, Antiviral Nucleosides: Chiral Synthesis and Chemotherapy, Elsevier, Amsterdam, Belgija, 2003.,
3. Mladen Mintas, Silvana Raić-Malić, Medicinska kemija, Medicinska naklada, Zagreb, 2009.,
4. Mladen Mintas, Medicinska kemija protutumorskih lijekova, Medicinska naklada, Zagreb, 2013.,
5. D. E. Thurston, Chemistry and Pharmacology of Anticancer Drugs, CRC Press, Taylor & Francis Group, New York, USA, 2007.,
6. E. De Clercq, Advances in Antiviral Drug Design, Elsevier Science, Ltd., Amsterdam, Belgija, 2004.,
7. Nenad Raos, Silvana Raić-Malić, Mladen Mintas, Lijekovi u prostoru: farmakofori i receptori, Školska knjiga, Zagreb, 2005.,

Izborna grupa - Regular modul - Applied Organic Chemistry