1. komponenta

Lecture type	Total
Lectures	30
Laboratory exercises	30

* Load is given in academic hour (1 academic hour = 45 minutes)

To acquaint students with the principles and basic principles of green chemistry and green organic synthetic methods. Comparison of classical thermal reactions of organic synthesis with methods of green organic chemistry. Application of green organic synthesis methods in the preparation of different classes of organic compounds, with special emphasis on heterocyclic derivatives.

1. Introduction, principles and basic principles of green chemistry.
2. Theory of microwave synthesis and microwaves. Comparison of microwave and classical heating. Microwave reactors for organic synthesis. Microwave synthesis techniques.
3. Microwave synthesis reactions carried out without solvent or in water. Transition metals as catalysts in the microwave synthesis of heterocycles. Palladium-catalyzed reactions.
4. How to start with microwave synthesis? Development and optimization of the method. Solvent selection. Safety aspects.Scale-up microwave-assisted organic syntheses.
5. Synthesis of organic compounds in environmentally friendly solvents. Application of solid phases in the synthesis of organic molecules.
6. Structure and properties of ionic liquids. Application of ionic liquids in organic synthesis. Syntheses in supercritical fluids.
7. 1st Partial test.
8. Application of ultrasonic waves in the synthesis of organic molecules.
9. Principles and principles of mechanochemical synthesis in organic chemistry.
10. Synthesis of heterocyclic compounds using multicomponent reactions.
11. Catalytic reactions. Green chemistry reactions without solvents.
12. Application of eutectic solvents in green organic synthesis.
13. 2nd Partial test.
14. Presentation of the seminars.
15. Presentation of the seminars.

1. Define, analyze and become familiar with the basic principles and principles of green organic chemistry and synthesis.
2. Define, analyze and become familiar with the basic principles of microwave, ultrasonic, mechanochemical and multicomponent organic synthesis.
3. Get to know and think critically about the application of ionic liquids, supercritical fluids, green and eutectic solvents in organic synthesis.
4. Become familiar with the application of green organic synthetic chemistry methods in the synthesis of target molecules.
5. Recognize the differences between classical organic synthesis and synthetic methods of green chemistry.
6. Present and interpret an overview of the synthesis of heterocyclic compounds prepared by some of the methods of green organic chemistry.
7. Synthesize organic compounds using synthetic methods of green chemistry.

1. PRACTICAL MICROWAVE SYNTHESIS FOR ORGANIC CHENMISTS, C.O.Kappe, D.Dallinger, S.S.Murphree, Wiley-WCH Weinheim, 2009.
2. GREEN TECHNIQUES FOR ORGANIC SYNTHESIS AND MEDICINAL CHEMISTRY, poglavlja I i III, W. Zhang, B. W. Cue, Wiley-WCH 2nd Ed. New jersey, SAD, 2018.
3. A TEXTBOOK OF GREEN CHEMISTRY, poglavlja 3, 4, 5, 8 i 10, S. P. Dey, N. Sepay, Techno World, 1st Ed.,Kolkata, India, 2021.
4. RADNI MATERIJAL S PREDAVANJA I NASTAVNI RECENZIRANI MATERIJAL, M. Hranjec,

Izborna grupa - Regular modul - Applied Organic Chemistry