The proposed research project is oriented towards the design, synthesis, and structural characterization of novel benzazole derivatives as promising agents with antitumor and antibacterial activity. The project is highly multidisciplinary and brings together an interdisciplinary team of 9 researchers whose common synergy will lead to the achievement of the main project goals and objectives. The project will consist of three main objectives including synthesis and structural characterization of benzazole derivatives, optimization and development of novel green synthetic methods and biological evaluation. Within the project synthesis of benzazole library will be achieved, while additionally this collaborative research should result in the optimization of the benzazole structural core which will ensure better efficiency, activity, selectivity, and optimized physico-chemical and biological properties in the search for lead compounds. Structural optimization as well as studying of the biological action will be aided by computational chemistry. Biological evaluation will include in vitro assays for evaluation of antiproliferative and antibacterial activity. Additionally, the chosen active compounds will be evaluated in additional antitumor and/or antibacterial assays to study the mechanisms of their biological action by choosing specific biological targets. To get more insight into the mechanisms of action of lead compounds, the electrochemical evaluation and interaction with DNA/RNA will be studied. Based on the principles of modern drug approach, the correlation and synergy beetwen compounds with promising antitumor and antibacterial activity will be studied. Finally, the presented research is based on joint research of different institutions including researchers from different scientific fields. Proposed project is based on the research in the field of medicinal chemistry with focus on possible further target research as well as further development of our scientific group on the international level.

Figure 1.The main objectives and activities of the proposed project