1. komponenta

Lecture type	Total
Lectures	20

* Load is given in academic hour (1 academic hour = 45 minutes)

General description of the course:
Introduction in concepts: biochemical engineering, bioreaction engineering, bioprocess engineering, metabolic engineering, genetic engineering, bioseparation processes. Integrated bioprocesses. Macrokinetics. Bioprocess engineering: the critical time concept, relations between parameters, the optimization scheme. Economic analysis of bioprocesses: components of the cost estimate, process flow sheets, material and energy balances in process design, equipment sizing. Capital cost estimates. Manufacturing cost estimates. Homogeneous and heterogeneous biocatalysis concept. Biocatalysis and biotransformations. Strategy for continuous biotransformation process development. Optimisation of biotransformation processes. Genetic algorithm and EVOP. Development and optimization of processes performed in enzyme membrane reactor and microreactor. Economical and environmental aspects of biotransformation processes. Mathematical modelling of biotransformation processes. Unstructured and structured kinetic models of biomass growth, substrate uptake and product formation. Metabolic flux analysis. ATP balances. Development, optimization and modelling of biotransformation processes with fully integrated separation of products.
DESCRIPTION OF TEACHING METHODS
Teaching methods individually tailored to the student: lectures and / or consultations
DESCRIPTION OF THE EXECUTION OF OBLIGATIONS
Preparation of an independent seminar paper related to a topic of scientific or professional interest for a student.
LEARNING OUTCOMES OF THE COURSE
To setup the design-of-experiments with the aim of optimising the conditions of biotransformation processes using stochastic and statistical methods.
To develop mathematical models of biotransformation processes for different types of bioreactors.
To estimate kinetic parameters of a biochemical reaction on the basis of experimental data.
To calculate the consumption of biocatalysts and volume productivity for a given reaction system and different types of bioreactors.
To select the most suitable type of bioreactor for a given reaction system based on the results of the experiment and the simulation results of a mathematical model of the process.
To conduct economic and environmental analysis of biotransformation processes.
LEARNING OUTCOMES AT PROGRAM LEVEL
Systematize knowledge, skills and competencies for process development in chemical engineering
Evaluate skills and methods of experimental and theoretical research in chemical engineering
LITERATURA:
James E. Bailey, David F. Ollis. (1983). Biochemical Engineering Fundamentals. McGraw-Hill Education

1. To setup the design-of-experiments with the aim of optimising the conditions of biotransformation processes using stochastic and statistical methods.
2. To estimate kinetic parameters of a biochemical reaction on the basis of experimental data.
3. To develop mathematical models of biotransformation processes for different types of bioreactors.
4. To calculate the consumption of biocatalysts and volume productivity for a given reaction system and different types of bioreactors.
5. To select the most suitable type of bioreactor for a given reaction system based on the results of the experiment and the simulation results of a mathematical model of the process.
6. To conduct economic and environmental analysis of biotransformation processes.

1. Biochemical Engineering Fundamentals, James E. Bailey, David F. Ollis, McGraw-Hill Education, 1983.

D_Temeljni - Regular studij - Chemical Engineering and Applied Chemistry